| Company | Industry | Employment |
| Parkview Health Systems | General Medical and Surgical Hospitals | 10,930 |
| Lutheran Health Network | General Medical and Surgical Hospitals | 5,317 |
| Zimmer Biomet | Orthopedic Supplies | 4,370 |
| General Motors | Trucks | 3,900 |
| Steel Dynamics | Scrap Metal Processing and Steel Manufacturing | 2,902 |
| Sweetwater Sound | Sound Recording Studio and Equipment Distribution | 1,970 |
| Lincoln Financial Group | Insurance Products | 1,954 |
| LSC Communications | Books and Other Specialized Printing | 1,585 |
| BAE Systems | Aerospace/defense contractor | 1,550 |
| BFGoodrich | Tires | 1,475 |
| Thor Industries, Inc. | Recreational Vehicles and Travel Trailers | 1,467 |
| TI Automotive | Fluid Storage, Transfer, and Delivery Systems | 1,388 |
| Frontier | Call Center | 1,355 |
| REV Recreation Group | Recreational Vehicles | 1,200 |
| DePuy Synthes | Orthopedic Supplies | 1,176 |
Source: Purdue University Fort Wayne Community Research Institute and Developers Counsellors International, Q1 2021